Quassinoids: Anticancer and Antimalarial Activities
Identifieur interne : 001180 ( Main/Exploration ); précédent : 001179; suivant : 001181Quassinoids: Anticancer and Antimalarial Activities
Auteurs : Emeline Houël [France] ; Didier Stien [France] ; Geneviève Bourdy [France] ; Eric Deharo [France]Source :
Abstract
Abstract: Quassinoids were initially isolated as bitter principles of plants of the Simaroubaceae family. These natural products are formed by oxidative degradation of triterpene derivatives. Since the 1970s, these molecules have attracted attention because of their promising biological activities, especially in the context of research regarding active anticancer and antimalarial principles. In this chapter, the structural diversity of quassinoids and their botanical and geographical occurrence are described, combining a historical perspective from the literature references regarding these two major biological activities and focusing on the results obtained in vivo with the most promising compounds; in vitro studies are less relevant and have already been extensively reviewed in the literature. The biological activities with respect to the uses of the corresponding Simaroubaceae in traditional medicine are also analyzed. Species names have been transcribed according to the nomenclature system used by The Plant List ( http://www.theplantlist.org ). Full names of species with determinant are given when cited for the first time only.
Url:
DOI: 10.1007/978-3-642-22144-6_161
Affiliations:
- France
- Guyane, Midi-Pyrénées, Occitanie (région administrative), Île-de-France
- Cayenne, Gif-sur-Yvette, Toulouse
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These natural products are formed by oxidative degradation of triterpene derivatives. Since the 1970s, these molecules have attracted attention because of their promising biological activities, especially in the context of research regarding active anticancer and antimalarial principles. In this chapter, the structural diversity of quassinoids and their botanical and geographical occurrence are described, combining a historical perspective from the literature references regarding these two major biological activities and focusing on the results obtained in vivo with the most promising compounds; in vitro studies are less relevant and have already been extensively reviewed in the literature. The biological activities with respect to the uses of the corresponding Simaroubaceae in traditional medicine are also analyzed. Species names have been transcribed according to the nomenclature system used by The Plant List ( http://www.theplantlist.org ). Full names of species with determinant are given when cited for the first time only.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Guyane</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Île-de-France</li></region><settlement><li>Cayenne</li><li>Gif-sur-Yvette</li><li>Toulouse</li></settlement></list><tree><country name="France"><region name="Guyane"><name sortKey="Houel, Emeline" sort="Houel, Emeline" uniqKey="Houel E" first="Emeline" last="Houël">Emeline Houël</name></region><name sortKey="Bourdy, Genevieve" sort="Bourdy, Genevieve" uniqKey="Bourdy G" first="Geneviève" last="Bourdy">Geneviève Bourdy</name><name sortKey="Bourdy, Genevieve" sort="Bourdy, Genevieve" uniqKey="Bourdy G" first="Geneviève" last="Bourdy">Geneviève Bourdy</name><name sortKey="Deharo, Eric" sort="Deharo, Eric" uniqKey="Deharo E" first="Eric" last="Deharo">Eric Deharo</name><name sortKey="Deharo, Eric" sort="Deharo, Eric" uniqKey="Deharo E" first="Eric" last="Deharo">Eric Deharo</name><name sortKey="Houel, Emeline" sort="Houel, Emeline" uniqKey="Houel E" first="Emeline" last="Houël">Emeline Houël</name><name sortKey="Stien, Didier" sort="Stien, Didier" uniqKey="Stien D" first="Didier" last="Stien">Didier Stien</name><name sortKey="Stien, Didier" sort="Stien, Didier" uniqKey="Stien D" first="Didier" last="Stien">Didier Stien</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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